Federal agents in the United States have shot and injured two people in the city of Portland, Oregon, a city where the administration of President Donald Trump has led an immigration enforcement crackdown.

The shooting was the second time in less than a day that federal immigration authorities claimed to have fired upon a vehicle in self-defence, following a deadly shooting in Minneapolis, Minnesota.

On Thursday, the Portland Police Department announced they had responded to reports of gunfire on southeast Main Street at about 2:18pm local time (22:18 GMT).

“Officers confirmed that federal agents had been involved in a shooting,” the city said in a statement.

Emergency responders then received a call for assistance from one of the shooting victims, a man, at about 2:24pm (22:24 GMT) near Northeast 146th Avenue and East Burnside in Portland’s Hazelwood neighbourhood.

“Officers responded and found a male and female with apparent gunshot wounds,” the statement said. “Officers applied a tourniquet and summoned emergency medical personnel.”

The two shooting victims were transported to hospital. Their conditions remain unknown, according to the police, who were not involved in the shooting.

The local bureau of the Federal Bureau of Investigation (FBI) confirmed the shooting in a now-deleted post on social media, saying that the incident involved Customs and Border Patrol (CBP) agents.

“This remains an active and ongoing investigation led by the FBI,” Portland’s FBI bureau said in the post.

Later, the Department of Homeland Security (DHS) offered its own account of what happened, describing the shooting as self-defence during a “targeted vehicle stop”.

In a social media post, DHS said its target was a passenger travelling inside a vehicle, who was affiliated with a “transnational Tren de Aragua prostitution ring and involved in a recent shooting”. The driver, DHS claimed, was a member of Tren de Aragua, a Venezuelan gang.

“When agents identified themselves to the vehicle occupants, the driver weaponized his vehicle and attempted to run over the law enforcement agents,” DHS said in the post.

“Fearing for his life and safety, an agent fired a defensive shot. The driver drove off with the passenger, fleeing the scene.”

Second agent-involved shooting

Details about Thursday’s shooting remain unknown. But the administration of President Donald Trump has faced criticism for misrepresenting incidents where federal agents deployed violence as part of its nationwide immigration crackdown.

The Portland shooting comes one day after an agent with Immigration and Customs Enforcement (ICE) shot and killed Renee Nicole Good, a 37-year-old mother of three, in her car in Minneapolis, Minnesota.

“Just one day after the horrific violence in Minnesota at the hands of federal agents, our community here in Portland is now grappling with another deeply troubling incident,” Portland Mayor Keith Wilson said in a statement.

“We cannot sit by while constitutional protections erode and bloodshed mounts.”

Good’s death has triggered widespread outrage, as well as criticism that the Trump administration rushed to disseminate a misleading narrative about the Minneapolis shooting.

Video of Good’s shooting showed the 37-year-old stopped in her SUV on a snowy Minneapolis road, appearing to wave other drivers by.

A vehicle carrying ICE officers stopped next to her vehicle, and agents approached her, reaching for the handle of her car door. One approached the front of her vehicle. As her car appeared to turn and manoeuvre away, that agent fired multiple times into the vehicle, killing Good.

In that case, too, Trump administration officials claim the ICE agent acted in self-defence, despite the fact that the vehicle did not seem to make contact with his body.

Trump asserted – without evidence – that Good was a “professional agitator” who “violently, willfully, and viciously ran over the ICE Officer”. Homeland Security Secretary Kristi Noem also accused Good of a “domestic act of terrorism”, despite there being no evidence Good sought to harm the ICE agent.

Democratic officials have accused the Trump administration of spreading false narratives to distract from its own abuses during the immigration crackdown.

Still, officials in Portland repeatedly called for calm in the aftermath of Thursday’s shooting, while acknowledging the parallels between the incidents.

“We are still in the early stages of this incident,” Portland Police Chief Bob Day said in a statement.

“We understand the heightened emotion and tension many are feeling in the wake of the shooting in Minneapolis, but I am asking the community to remain calm as we work to learn more.”

Mayor Wilson, meanwhile, called for federal immigration agents to leave the city, arguing that they had endangered local citizens with their heavy-handed actions.

“Portland is not a ‘training ground’ for militarized agents, and the ‘full force’ threatened by the administration has deadly consequences,” Wilson said.

“As Mayor, I call on ICE to end all operations in Portland until a full investigation can be completed. Federal militarization undermines effective, community‑based public safety, and it runs counter to the values that define our region.”

Oregon Senator Jeff Merkley, meanwhile, expressed “huge concern” over the incident and suggested that responding with anger would only fuel the Trump administration’s fixation with Portland.

“Trump wants to generate riots,” he wrote. “Don’t take the bait.”

Portland under a microscope

Portland has long been a focal point of Trump’s immigration enforcement actions, and the increased federal presence has ignited largely nonviolent protests in response.

Long seen as a Democratic stronghold, Portland was identified in May as one of the “sanctuary jurisdictions” that the Trump administration identified as resisting its immigration crackdown.

The Republican president hinted he could surge federal agents to the area in response.

In September, those threats appeared to materialise when Trump wrote on his Truth Social platform that he would be sending the US military to support immigration operations in the city.

The announcement came five days after Trump declared antifa – the loose-knit antifascist movement – a “domestic terrorist organisation”.

“I am directing Secretary of War, Pete Hegseth, to provide all necessary Troops to protect War ravaged Portland, and any of our ICE Facilities under siege from attack by Antifa, and other domestic terrorists,” Trump wrote. “I am also authorizing Full Force, if necessary.”

It was the latest in the string of instances where Trump attempted to send federal troops to largely Democratic urban areas, including Los Angeles and Chicago, Illinois.

Local officials denounced the deployment as a violation of the law and a misuse of executive authority. But the Trump administration doubled down, describing Portland as overrun by criminal behaviour.

“ In Portland, Oregon, antifa thugs have repeatedly attacked our officers and laid siege to federal property in an attempt to violently stop the execution of federal law,” Trump said at an October roundtable.

In response, some protesters in Portland began arriving in inflatable frog costumes, in an effort to cast Trump’s warnings about violent extremists as absurd. The Portland Frog Brigade, as the protesters were called, inspired similar demonstrations nationwide.

State and local leaders fought Trump’s troop deployment in court, and on November 7, US District Judge Karin Immergut permanently blocked the deployment.

The US Supreme Court in December declined the Trump administration’s appeal to allow National Guard troops in areas where lower courts had barred them.

On Thursday, Mayor Wilson called for accountability in the recent shootings, saying he would protect local residents’ civil liberties.

“ICE agents and their Homeland Security leadership must be fully investigated and held responsible for their violence against the American people, in Minnesota, in Portland, and across the nation,” he said.

He repeated the message that Portland residents should not seek retribution in the aftermath of the gunfire.

“Portland does not respond to violence with violence. We respond with clarity, unity, and a commitment to justice. We must stand together to protect Portland,” he said.